news

  • 11 April 2019
    InDex Pharmaceuticals provides status update on the patient recruitment in the CONDUCT study

    InDex Pharmaceuticals Holding AB (publ) today announced that 197 patients, of the total 215 planned, have been enrolled to date in the CONDUCT study evaluating the drug candidate cobitolimod. The patient recruitment has varied significantly on a monthly basis, with between 6 and 19 patients enrolled, which makes it challenging to predict the remaining recruitment time. The company estimates that the patient recruitment will be completed during the month of June at the latest, which represents a delay compared to the previously communicated timeline. The company will announce when the last patient has been enrolled in the study and the top line results are expected to be available within 8-10 weeks thereafter.

    Cobitolimod is a new type of drug under development for the treatment of moderate to severe ulcerative colitis. The CONDUCT study is a randomised, double blind, placebo-controlled study for evaluating cobitolimod’s efficacy and safety in inducing clinical remission compared to placebo in patients with left-sided moderate to severe active ulcerative colitis. The study is conducted at approximately 90 clinics in 12 European countries. The aim of the dose optimisation study is that more frequent and higher doses of cobitolimod will result in a significantly higher effect than in previous clinical studies with cobitolimod and also compared to what has been reported for products on the market and those in late stage clinical development.

    “We will soon have enrolled all the patients in the CONDUCT study and are preparing to analyse the results, which will be a crucial milestone for the company,” said Peter Zerhouni, CEO of InDex Pharmaceuticals. ”With positive data we will take a big step towards our goal to make cobitolimod available for these severely ill patients.”