• 13 February 2018
    InDex Pharmaceuticals presents mechanism of action data for cobitolimod at the ECCO congress

    InDex Pharmaceuticals Holding AB (publ) today announced that the recently reported new mechanism of action data for the drug candidate cobitolimod has been selected for an oral presentation at the 13th congress of the European Crohn’s and Colitis Organisation (ECCO).

    The scientific abstract, prepared in collaboration with the University of Erlangen-Nürnberg in Germany, has been selected amongst the top 10 out of 1,366 submitted abstracts, and it will feature in the Highlights of ECCO’18 video. The video will contain the most important scientific insights and take-home messages from the congress. The ECCO congress is the largest congress in the world with a specific focus on inflammatory bowel disease (IBD) and is held in Vienna, Austria on February 14-17, 2018. More than 6,000 delegates from all over the world are expected to attend the single track scientific programme.

    “We are very pleased that the scientific committee at ECCO considers the new mechanism of action data for cobitolimod to be one of the most interesting findings during this years’ congress”, says Peter Zerhouni, CEO of InDex Pharmaceuticals. “This event is a great opportunity for us to increase visibility in the scientific community and meet the investigators in our ongoing clinical study CONDUCT. It is a phase IIb dose optimisation study with cobitolimod in moderate to severe active ulcerative colitis and the objective is to have top line results from the study in the fourth quarter of this year.”

    The presentation (OP004) with the title The TLR9 agonist cobitolimod induces anti-inflammatory effects and balances the Th17/T-reg cell response in Ulcerative Colitis will be given by Dr Heike Schmitt from the University of Erlangen-Nürnberg on Thursday, February 15, 2018 in the Plenary Hall at 14:50 CET during the session Novel treatment strategies. The presentation will include mechanism of action data on cobitolimod in the standard experimental model of colitis as well as in ulcerative colitis patients, showing that cobitolimod can modulate the immune system in ulcerative colitis by balancing the mucosal Th17/Treg cell response. Cobitolimod treatment decreases IL-17 expression and the number of Th17 cells, while it increases mucosal IL-10 expression and the quantity of T-reg cells. In conclusion, cobitolimod addresses new therapeutic targets in the immunopathogenesis of ulcerative colitis, leading to pronounced anti-inflammatory effects.