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  • 8 September 2017
    Arsanis Presents Preclinical Data on Lead Product Candidate, ASN100, at the “2017 ASM/ESCMID Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance”

    Arsanis, Inc., a clinical-stage biopharmaceutical company focused on applying monoclonal antibody immunotherapies to address serious infectious diseases, today announced that the company presented positive preclinical efficacy data in prevention and treatment models of lethal Staphylococcus aureus pneumonia for its investigational lead product candidate, ASN100, which is currently in a Phase 2 clinical trial for the prevention of S. aureus pneumonia in high-risk, mechanically ventilated patients. These data were described in two poster presentations at the 2017 ASM/ESCMID Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, taking place in Boston from September 6 – 8. 

    “The preclinical data presented at the ASM/ESCMID meeting further support the development of ASN100, a firstin-class monoclonal antibody therapeutic with a non-antibiotic mechanism of action,” said Eszter Nagy, M.D., Ph.D., Co-Founder, and Chief Scientific Officer of Arsanis. “ASN100 monotherapy demonstrated complete protection against a range of S. aureus strains in a preventative rabbit model of S. aureus pneumonia.The data also indicate the therapeutic potential of ASN100, demonstrating the importance of broad neutralization of cytotoxins critical to S. aureus pneumonia.”

    Summary of Posters

    Prophylactic Efficacy and Pharmacokinetics of Cytotoxin-Neutralizing Monoclonal IgGs in Rabbit Models of Staphylococcus aureus Pneumonia. Poster #99.

    In this study of ASN100 in a rabbit model of the prevention of lethal S. aureus pneumonia, ASN100 elicited high protective efficacy against all S. aureus strains tested irrespective of antibiotic susceptibility and toxin expression profiles. Significant dose-dependent protection was observed with the highest doses achieving 100 percent (100%) survival at 96 hours in this acute pneumonia model. Improved lung pathology, including reduced tissue damage, edema rates and bacterial burden were also observed with ASN100 therapy.

    Potentiating Antibiotics with Cytotoxin-Neutralizing Monoclonal Antibodies in Lethal Murine and Rabbit Models of Staphylococcus aureus Pneumonia. Poster #102.

    In these studies, Arsanis tested ASN100 as monotherapy and in combination with antibiotics in mouse and rabbit treatment models of S. aureus pneumonia. These studies demonstrated efficacy of ASN100 monotherapy and notably, when dosed in combination with antibiotics, potentiation of antibiotic efficacy, including efficacy of betalactam antibiotics against methicillin resistant S. aureus (MRSA) strains.